Advanced Vancomycin AUC/MIC & Dosing Calculator

Based on the mathematical models utilized by GlobalRPH (2019) Advanced Pharmacokinetic Dosing Calculator.
Patient-Specific Data
Patient: Location:
Age: years Sex: Male Female
Serum Creatinine:
Height: Weight:
Clearance method: Cockcroft and Gault using ibw (default)
Cockcroft and Gault-Adjusted body wt (BMI over 25)

Use weight for vanco dosing:
Use Actual (total) weight
Use Adjusted body weight
Drug Data Entries (Vancomycin)
Desired Peak: Desired Trough:
Volume of distribution (L/kg):
 Infusion time (hrs):

Elimination rate constant (Ke) calculation:
Calculated Values
BMI: - Serum Creatinine: -
IBW: - Adjusted body weight: -
Dosing weight (kg): - CRCL (ml/min): -
Kel (hr-1): - T 1/2 (hrs): -
Vd (liters): - Vanco CL (L/hr): -
Recommended Dose and Predicted Levels
Recommended Dose: - Recommended Interval: -
Predicted peak: - mcg/ml Predicted trough: - mcg/ml
Enter New (Rounded Values)
Enter New dose: mg Enter New interval: hrs Infusion time: hrs

Final Values - New Regimen
Expected Peak Expected Trough Daily Dose
- mcg/ml - mcg/ml -
Vancomycin AUC/MIC General target range for optimal PK/PD efficacy while minimizing the risk of nephrotoxicity: 400-600 assuming an MIC of 1 mg/L.

MIC 1.0 mcg/mL: AUC/MIC: -
-
MIC 0.5 mcg/mL:
AUC/MIC: -		 MIC 1.5 mcg/mL:
AUC/MIC: -		 MIC 2.0 mcg/mL:
AUC/MIC: -
Vancomycin Loading Dose Estimate

Purpose: decreases the risk of subtherapeutic concentrations during the first days of therapy.
(Note: infusion times are set to 15 mg/min). NA values indicate that the loading dose was too low to generate the current concentration.

Loading Dose Peak post infusion Time to 20 mcg/mL Time to 15 mcg/mL

Disclaimer: This section provides calculations based on user-entered parameters. It is up to the end-user to determine the appropriateness of the dosing.
© 2019 GlobalRPH logic clone.